It’s no surprise that many of the highly processed foods we consume pack just as much of a dopamine punch as alcohol, drugs, sex, and rock n’ roll. As restaurants and food-product businesses compete for our loyalty, the concentrations of flavor enhancers in what we now know as “hyperpalatable” foods have skyrocketed. But what exactly are flavor enhancers and how do they cause food cravings? Here we talk about these very products and describe how to regain control over our addictive eating habits. We can not only take back our independence from food cravings, but we can also help those we work with do the same!

While you may already know that dopamine, aka the “pleasure chemical,” functions as an important neurotransmitter, or messenger between neurons, you may not know that the release of dopamine in the brain often starts at the tongue.

Our tongue is an oasis of sensory receptors that absorb distinct flavor profiles, textures, and more. Our tongue’s taste buds act as a gateway that receives information from our food and translates it into both pleasurable and non-pleasurable signals. These signals suggest to our body which foods can either enhance or detract from our living experience.

Each of us has a pathway that connects the taste buds on our tongue to dopamine producing cells in our brain. This pathway is known as the gustatory system, and it is where pleasure from eating food starts. When we immerse our tongue in an experience with hyper-concentrated sugar, salt, or carbohydrates (i.e. hyperpalatable foods), dopamine levels surge in the part of our brain known as the nucleus accumbens. Furthermore, the greater the release of dopamine, the greater the sensation of pleasure. Ultimately, this is how we experience pleasure from food.

The Problem
Experiencing pleasure from food that contains natural amounts of sugar, salt and carbohydrates isn’t a bad thing, but a problem arises when we ingest high concentrations of these flavor enhancers in our food. For example, whereas one entire whole fruit, such as a medium orange, contains 12 grams of sugar, a one-pint glass of orange juice (a processed food product) contains a whopping 40 grams of sugar! That is more than a can of your favorite soda. And when we recurrently trigger a surge in dopamine by repeatedly ingesting high amounts of sugar, our dopamine levels start dropping. Repeated doses of high amounts of sugar, salt, or carbohydrates also trigger a reduction in a specific type of dopamine receptor known as the dopamine 2 (D2) receptor. These receptors are decreased not only in individuals suffering from food addiction, but also in people who are addicted to alcohol and drugs such as tobacco, cocaine, methamphetamine, and opiates. A lower number of D2 receptors means there are fewer opportunities for dopamine to bind to these receptors. These reductions in dopamine and D2 receptors result in a condition known as Reward Deficiency Syndrome (RDS) which produces cravings.

We need modest amounts of dopamine in our everyday lives, and we can get a healthy amount of dopamine simply by exposing ourselves to sunshine, talking with friends, or moving our bodies. But when we fry our pleasure receptors by dumping excessive amounts of dopamine after consuming hyperpalatable foods, we crave more of these dopamine-releasing foods.

The Solution
Don’t be disheartened! There is good news for those who have already journeyed deep into the depths of food addiction. We can recover from our addiction by growing new dopamine receptors. How is this possible? As already described, a high carbohydrate diet decreases D2 receptors. But we can increase the number of D2 receptors in our brain by eating a diet that is high in healthy fats. Also, restricting our intake of food for extended periods of time similarly increases dopamine receptors.

Thus, dietary changes such as eating a high-fat diet and utilizing intermittent fasting can help increase the number of dopamine receptors in our brain, thus reducing food cravings and boosting our ability to experience happiness.

References

Alsiö, Johan, et al. "Exposure to a high-fat high-sugar diet causes strong up-regulation of proopiomelanocortin and differentially affects dopamine D1 and D2 receptor gene expression in the brainstem of rats." Neuroscience Letters 559 (2014): 18-23.

Blum, Kenneth, et al. "Reward circuitry dopaminergic activation regulates food and drug craving behavior." Current pharmaceutical design 17.12 (2011): 1158-1167.

Chen, Wei, et al. "Aerobic exercise improves food reward systems in obese rats via insulin signaling regulation of dopamine levels in the nucleus accumbens." ACS chemical neuroscience 10.6 (2019): 2801-2808.

de Araujo, Ivan E., Xueying Ren, and Jozélia G. Ferreira. "Metabolic sensing in brain dopamine systems." Sensory and metabolic control of energy balance (2010): 69-86.

Hamdi, Anwar, Emmanuel S. Onaivi, and Chandan Prasad. "A low protein-high carbohydrate diet decreases D2 dopamine receptor density in rat brain." Life sciences 50.20 (1992): 1529-1534.

Krach, Sören, et al. "The rewarding nature of social interactions." Frontiers in behavioral neuroscience 4 (2010): 1141.

Rada, Pedro, Nicole M. Avena, and Bartley G. Hoebel. "Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell." Neuroscience 134.3 (2005): 737-744.

Small DM, Jones-Gotman M, Dagher A (2003) Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 19:1709–1715.

South, Timothy, and Xu-Feng Huang. "High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice." Neurochemical research 33 (2008): 598-605.

Thanos, Panayotis K., et al. "Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in‐vivo μPET imaging ([11C] raclopride) and in‐vitro ([3H] spiperone) autoradiography." Synapse 62.1 (2008): 50-61.

Trifilieff, Pierre, and Diana Martinez. "Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity." Neuropharmacology 76 (2014): 498-509.

Tsai, Hsiang-Yi, et al. "Sunshine-exposure variation of human striatal dopamine D2/D3 receptor availability in healthy volunteers." Progress in Neuro-Psychopharmacology and Biological Psychiatry 35.1 (2011): 107-110.

QOSHE - The Neurochemistry of Food Cravings - Mitchell B. Liester M.d
menu_open
Columnists Actual . Favourites . Archive
We use cookies to provide some features and experiences in QOSHE

More information  .  Close
Aa Aa Aa
- A +

The Neurochemistry of Food Cravings

13 0
14.03.2024

It’s no surprise that many of the highly processed foods we consume pack just as much of a dopamine punch as alcohol, drugs, sex, and rock n’ roll. As restaurants and food-product businesses compete for our loyalty, the concentrations of flavor enhancers in what we now know as “hyperpalatable” foods have skyrocketed. But what exactly are flavor enhancers and how do they cause food cravings? Here we talk about these very products and describe how to regain control over our addictive eating habits. We can not only take back our independence from food cravings, but we can also help those we work with do the same!

While you may already know that dopamine, aka the “pleasure chemical,” functions as an important neurotransmitter, or messenger between neurons, you may not know that the release of dopamine in the brain often starts at the tongue.

Our tongue is an oasis of sensory receptors that absorb distinct flavor profiles, textures, and more. Our tongue’s taste buds act as a gateway that receives information from our food and translates it into both pleasurable and non-pleasurable signals. These signals suggest to our body which foods can either enhance or detract from our living experience.

Each of us has a pathway that connects the taste buds on our tongue to dopamine producing cells in our brain. This pathway is known as the gustatory system, and it is where pleasure from eating food starts. When we immerse our tongue in an experience with hyper-concentrated sugar, salt, or carbohydrates (i.e. hyperpalatable foods), dopamine levels surge in the part of our brain known as the nucleus........

© Psychology Today


Get it on Google Play