In the realm of medical anomalies, few conditions captivate curiosity and concern quite like aquagenic urticaria, commonly known as “water allergy”.

This rare affliction transforms the seemingly innocuous act of water contact into a tormenting ordeal, afflicting people such as 22-year-old Loren Montefusco from South Carolina, US.

Diagnosed with water allergy, Montefusco’s life is marked by the excruciating sensation of a burning itch deep beneath her skin. This is triggered by the mere touch of water. Her account reveals the harrowing experiences faced by those grappling with this puzzling condition.

At its core, water allergy is believed to arise from an abnormal immune response triggered by water’s interaction with the skin. Think of your immune system as a vigilant guardian, always on alert for invaders. In aquagenic urticaria, water somehow triggers an alarm response. This leads to the release of substances like histamine – causing hives, welts and itching.

Researchers have pinpointed mutations in specific genes associated with water allergy, such as the FABP5 gene,........

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