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Israeli drug candidate slows Alzheimer’s-causing protein in mouse brains

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Israeli scientists say they have developed a drug that slows protein deposits on the brain that are a cause of Alzheimer’s disease, and say it may also be used for treating some autism cases.

The Tel Aviv University team behind the peer-reviewed research saw an improvement in the symptoms of mice. The biggest success, they say, was a dramatic decrease in the excessive buildup of a protein in the brain called tau. The protein performs important functions in normal brains, but among Alzheimer’s patients it tends to build up excessively, and becomes misfolded and abnormally shaped.

The scientists edited the genomes of the mice to give them a rare developmental disorder called ADNP syndrome, which involves a range of symptoms, many of them close to those of Alzheimer’s.

For years, biochemist Prof. Illana Gozes........

© The Times of Israel

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