InnovationRx: Regrowing Cartilage To Fix Damaged Knees And Ankles

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Vericel CEO Nick Colangelo

Persistent knee pain is sometimes caused by damage to the cartilage that lines the end of the bones that form the knee. That damage can be caused by injury or just result from wearing down over time. One potential treatment for this is MACI, offered by Vericel.

With MACI, a surgeon will take a small sample of a patient’s own knee cartilage, which is then multiplied in a petri dish over time. Then, the cartilage is reinserted into the knee along with a dissolvable “scaffold” that helps ensure that it grows properly, helping to repair the joint.

MACI, approved by the FDA in 2016, is already a major revenue driver for Vericel with over $84 million in sales in the first half of 2024, representing growth of about 20% year over year. In August, the FDA approved arthroscopic administration of MACI, a much less invasive procedure that........

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