Closing the genomics gap: How to improve indigenous health

Nestled amongst subtle genetic differences are clues for why many of us develop diseases, like cancer, and how we respond to medical treatments for them.

We share 99.9% of human DNA — the sequence of genes, or biological information, that allows us to function and live. But the 0.1% of human DNA that differs in each of us can reveal why we have different health outcomes.

There's a lot of research into genetics and genomics as these fields can explain how genes are passed from generation to generation, and how all of our genes together — our genomes — make us more or less likely to develop a disease.

The problem is that more than 80% of genetics studies include only people from European descent. As a result, they represent no more than 20% of the worldwide population. And that is leading to what some experts an injustice in medicine — or a "genomics gap".

"There is an injustice in medicine, particularly in genetics: we know much more about the genetic basis of diseases for people of European ancestry [Europeans or US-whites] than for people with other origins," said Eduardo Tarazona-Santos, a geneticist at Universidade Federal de Minas Gerais in Brazil.

Tarazona-Santos has been working to fix this injustice, gathering data about genetic differences in two indigenous populations in Latin America — one in the Andean highlands and........

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